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9 The STEP-HFpEF DM randomised controlled trial enrolled 616 patients with obesity (BMI 30 kg/m 2 ) and both HFpEF (LVEF 40%) and T2D

26,107 Although neuronal regulation of GLP-1 secretion is not well-studied in humans, studies using rodents have found that GLP-1 secretion from L-cells in response to GIP stimulation is induced by the nervous system

Inflammatory Balance : Adipose tissue inflammation is a key factor in metabolic dysfunction

That said, its been shown to be extremely effective for weight loss, too

Colchicine and IL-1 inhibitor Canakinumab showed a reduction in major cardiovascular events in patients with previous myocardial infarction, but with no benefits on death by any cause [15,16,17]